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Shigeyoshi Itohara Selected Research

Intellectual Disability (Idiocy)

7/2021Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome.
1/2019Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.
1/2018Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

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Shigeyoshi Itohara Research Topics

Disease

7Seizures (Absence Seizure)
01/2021 - 05/2002
5Epilepsy (Aura)
01/2019 - 05/2002
4Schizophrenia (Dementia Praecox)
01/2021 - 02/2005
4Neoplasms (Cancer)
05/2012 - 08/2002
3Intellectual Disability (Idiocy)
07/2021 - 01/2018
3Autistic Disorder (Autism)
01/2018 - 04/2007
3Alzheimer Disease (Alzheimer's Disease)
11/2016 - 12/2006
3Parkinson Disease (Parkinson's Disease)
11/2012 - 01/2007
3Infections
07/2010 - 06/2002
3Atherosclerosis
05/2006 - 09/2003
2Bipolar Disorder (Manic Depressive Psychosis)
01/2021 - 01/2021
2Myoclonic Epilepsies (Myoclonic Encephalopathy)
01/2020 - 12/2013
2Brain Diseases (Brain Disorder)
01/2020 - 12/2013
2Inflammation (Inflammations)
01/2015 - 04/2007
2Scrapie
11/2013 - 12/2010
2Necrosis
11/2012 - 08/2002
2Prion Diseases (Transmissible Spongiform Encephalopathies)
12/2010 - 06/2002
2Ataxia (Dyssynergia)
08/2007 - 05/2002
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
10/2004 - 12/2003
2Hyperplasia
09/2003 - 04/2002
1Kleefstra Syndrome
07/2021
1Major Depressive Disorder (Major Depressive Disorders)
01/2021
1Tremor (Tremors)
01/2021
1Drug Resistant Epilepsy
01/2021
1Glycosylphosphatidylinositol deficiency
01/2021
1Psychotic Disorders (Schizoaffective Disorder)
01/2021
1Mental Disorders (Mental Disorder)
01/2021
1Essential Tremor (Essential Tremors)
01/2021
1Febrile Seizures (Febrile Seizure)
01/2020
1Nervous System Diseases (Neurological Disorders)
01/2019
1Autism Spectrum Disorder
01/2019
1Male Infertility (Male Sterility)
01/2019
1Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)
10/2018
1Bites and Stings (Sting)
04/2015
1Temporal Lobe Epilepsy
12/2014
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
07/2014
1Chromosomal Instability (Chromosome Stability)
12/2013
1Premature Aging
12/2013
1Cataract (Cataracts)
12/2013
1Aneuploidy (Aneuploid)
12/2013
1Perinatal Death
10/2013
1Neurodegenerative Diseases (Neurodegenerative Disease)
11/2012
1AIDS-Related Complex (ARC)
12/2010
1Down Syndrome (Down's Syndrome)
03/2009
1Cleft Palate (Palate, Cleft)
06/2008
1Parkinsonian Disorders (Parkinsonism)
12/2007

Drug/Important Bio-Agent (IBA)

9Proteins (Proteins, Gene)FDA Link
07/2021 - 05/2005
9Matrix Metalloproteinases (MMPs)IBA
05/2007 - 08/2002
4Voltage-Gated Sodium ChannelsIBA
01/2020 - 12/2013
4Protein Isoforms (Isoforms)IBA
11/2013 - 06/2002
4Matrix Metalloproteinase 2 (Gelatinase A)IBA
01/2007 - 08/2002
3ParvalbuminsIBA
01/2020 - 05/2007
3Prion ProteinsIBA
11/2013 - 06/2002
3Matrix Metalloproteinase 14 (MT1-MMP)IBA
05/2007 - 06/2004
2CalciumIBA
01/2021 - 10/2004
2Cell Adhesion MoleculesIBA
01/2021 - 03/2009
2Amyloid (Amyloid Fibrils)IBA
11/2016 - 05/2014
2Messenger RNA (mRNA)IBA
12/2013 - 05/2006
2NeurotoxinsIBA
11/2012 - 12/2007
2Metalloproteases (Metalloproteinases)IBA
05/2012 - 08/2002
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
12/2010 - 02/2005
2PrionsIBA
12/2010 - 06/2002
2EnzymesIBA
04/2007 - 11/2006
2Tissue Inhibitor of Metalloproteinase-1IBA
05/2006 - 08/2002
2Tissue Inhibitor of Metalloproteinase-2IBA
05/2006 - 08/2002
1MethyltransferasesIBA
07/2021
1Lysine (L-Lysine)FDA Link
07/2021
1Histones (Histone)IBA
07/2021
1Immunoglobulin D (IgD)IBA
01/2021
1Kainic Acid (Kainate)IBA
01/2021
1Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA
01/2021
1HarmalineIBA
01/2021
1Heat-Shock Proteins (Heat-Shock Protein)IBA
01/2019
1Adenine Nucleotide Translocator 1IBA
10/2018
1Ethosuximide (Zarontin)FDA LinkGeneric
01/2018
1Nonsense Codon (Nonsense Mutation)IBA
01/2018
1Glutamic Acid (Glutamate)FDA Link
04/2015
1Retinaldehyde (Retinal)IBA
01/2015
1SialyltransferasesIBA
12/2014
1beta-Galactoside alpha-2,3-SialyltransferaseIBA
12/2014
1Dextran SulfateIBA
07/2014
1VimentinIBA
12/2013
1NestinIBA
02/2013
1Brain-Derived Neurotrophic Factor (BDNF)IBA
12/2012
1Receptor for Advanced Glycation End ProductsIBA
11/2012
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
11/2012
1CytokinesIBA
11/2012
1Serine (L-Serine)FDA Link
12/2010
1N-Methylaspartate (NMDA)IBA
12/2010
1Immunoglobulins (Immunoglobulin)IBA
12/2010
1CEACAM1 ProteinIBA
07/2010
1Pentylenetetrazole (Metrazol)IBA
03/2009
1gamma-Aminobutyric Acid (GABA)IBA
06/2008
1Ligases (Synthetase)IBA
12/2007
1UbiquitinIBA
12/2007
1NucleotidesIBA
08/2007
1Collagen Type IV (Type IV Collagen)IBA
05/2007

Therapy/Procedure

2Therapeutics
05/2007 - 12/2003
1Intravenous Injections
01/2020
1Lenses
12/2013